5-Hydroxymethylcytosine profiles in circulating cell-free DNA serve as potential biomarkers for diagnosis and classification of adenomyosis

Key Points

• The study aims to explore the potential of 5-hydroxymethylcytosine profiles in cell-free DNA as biomarkers for adenomyosis diagnosis and classification.
• Analyzed 5-hydroxymethylcytosine levels in circulating DNA samples.
• Compared profiles between individuals with and without adenomyosis.
• Utilized statistical analysis to evaluate diagnostic potential.
• Identified distinct 5-hydroxymethylcytosine patterns in adenomyosis cases.
• Demonstrated significant differences compared to controls.
• Suggested that these profiles could aid in diagnosis and classification of adenomyosis.