Graded aortic regurgitation in a mouse model induced severity-dependent atrial remodeling, with 62.5% of AR mice developing atrial fibrillation compared to 0% of sham mice.
Does graded aortic regurgitation induce severity-dependent atrial remodeling and atrial fibrillation vulnerability in a mouse model?
This preclinical mouse model demonstrates that aortic regurgitation directly induces severity-dependent arrhythmogenic atrial remodeling and AF vulnerability prior to overt ventricular pathology.
Absolute Event Rate: 62.5% vs 0%
The authors have declared that no conflict of
Lakin et al. (Thu,) conducted a other in Aortic regurgitation and atrial fibrillation (n=31). Aortic regurgitation (AR) via valve disruption vs. Sham surgery was evaluated on Development of atrial fibrillation (AF). Graded aortic regurgitation in a mouse model induced severity-dependent atrial remodeling, with 62.5% of AR mice developing atrial fibrillation compared to 0% of sham mice.