Self-collected versus clinician-collected samples for HPV testing: A meta-analysis revealing lower sensitivity for detecting high-grade cervical lesions

Key Points

• This research analyzes the effectiveness of self-collected versus clinician-collected samples for HPV testing.
• Conducted a meta-analysis comparing sensitivity and specificity of self-collected and clinician-collected samples.
• Included studies assessing high-risk HPV detection rates in both sample types.
• Evaluated the implications of sample collection method on screening outcomes.
• Self-collected samples show significantly lower sensitivity for detecting high-grade cervical lesions.
• Specificity between the two sample collection methods is comparable.
• Recommendations indicate using self-sampling with additional triage in certain settings.