What question did this study set out to answer?

Examine how depression affects all-cause mortality across different genders and age groups.

March 24, 2026

Analyzing the Impact of Depression on All-Cause Mortality in Different Sex and Age Groups: A 11-Year Follow-Up Study of Spanish Population

Key Result

Depression was significantly associated with all-cause mortality exclusively in men aged 65 and older.

Key Points

Examine how depression affects all-cause mortality across different genders and age groups.
Longitudinal study design
Follow-up of a Spanish population over 11 years
Analysis of gender and age-based differences in mortality related to depression
Depression linked to all-cause mortality specifically in men aged 65 and older
Identified gender-specific factors impacting help-seeking behavior
Highlighted the role of social isolation and chronic comorbidities in mortality risk

Structured PICO

Does depression impact all-cause mortality in different sex and age groups?

P

Population

Spanish population across different sex and age groups

I

Intervention

Depression (exposure)

O

Outcome

All-cause mortalityhard clinical

Depression is associated with all-cause mortality specifically in men over 65, highlighting the need for age- and gender-targeted preventive interventions.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

The depression and all-cause mortality relationship was found only in +65 men. These differences may be driven by gender-specific factors such as delayed help-seeking, higher levels of social isolation, and the accumulation of chronic comorbidities. Therefore, preventive interventions must prioritize age- and gender-specific strategies to address these risk patterns.