Direct access to ligand-like sulfonamide libraries via acid-catalyzed sulfinamide crossover

Key Points

• The aim is to develop a method to create diverse libraries of sulfonamides for identifying factor Xa ligands.
• Utilized sulfinamide S–N crossover technique
• Employed acid-catalysis
• Synthesized diverse sulfonamide libraries
• Successfully generated diverse ligand libraries
• Achieved oxidative locking of sulfonamides
• Enabled discovery of factor Xa ligands through AS-MS techniques