GLP-1 receptor agonists and sexual function in women and men: a narrative review of emerging evidence and the need for further research

Key Points

• The review aims to evaluate the effects of GLP-1 receptor agonists on sexual function across genders.
• Reviewed preclinical and clinical studies on GLP-1 receptor agonists and sexual function.
• Analyzed factors such as gender, metabolic status, and psychosocial influence on outcomes.
• Identified gaps and inconsistencies in existing research.
• Preclinical evidence suggests GLP-1 receptor activation may reduce sexual motivation.
• Human studies show mixed outcomes based on gender and other influencing factors.
• The need for more controlled studies is emphasized due to differences between preclinical and clinical findings.

Abstract