Advancing pesticide risk assessment: the role of adverse outcome pathways and new approach methodologies - what's next?

Key Points

• This research aims to evaluate the utility of adverse outcome pathways (AOPs) and new approach methodologies (NAMs) in pesticide risk assessments.
• Analyzed two case studies involving pesticide exposure and endocrine disruptors.
• Assessed the AOP construct for Parkinson's disease and uterine adenocarcinoma.
• Evaluated the strengths and limitations of proposed tests within a regulatory framework.
• Identified key strengths of using AOPs in risk assessment for pesticides.
• Highlighted limitations associated with current methodologies and testing approaches.
• Provided insights into the integration of AOPs and NAMs within existing regulatory frameworks.

Abstract