A full-adjusted BMI polygenic score model explained 39.6% of the mean-over-time excessive body weight loss in patients undergoing biliopancreatic diversion with duodenal switch.
Observational (n=540)
Does a BMI-derived polygenic score predict mean-over-time excessive body weight loss in patients with severe obesity undergoing bariatric surgery?
BMI-derived polygenic scores significantly, albeit modestly, improve the prediction of weight loss trajectories following bariatric surgery, highlighting their potential utility in personalized obesity management.
Effect estimate: Explained variance 39.6%
A large inter-individual variability in weight loss outcomes following bariatric surgery is reported. To ensure optimal patient management, it is crucial to accurately identify those most likely to benefit from the intervention. Since genetic variants largely contribute to surgery response, polygenic scores (PGS) derived from genome-wide association studies (GWAS) could constitute valuable tools for clinical decision making. We developed and evaluated PGS to predict the weight loss response in 540 patients with body mass index (BMI) ≥35kg/m2 who underwent biliopancreatic diversion with duodenal switch. Summary statistics derived from BMI-derived GWAS, together with summary statistics from previously published GWAS of BMI and adiposity features, were used to construct, evaluate, and benchmark weight-loss PGS. The full-adjusted BMI PGS model built in the entire cohort explained 39.6% of the mean-over-time excessive body weight loss (%EBWL), while the BMI-PGS built in the training dataset explained 38.9%. All benchmarked PGS based on BMI showed a significant relationship with mean-over-time %EBWL. These findings highlight the potential of BMI PGS in predicting weight loss after bariatric surgery and support their use as promising tools to improve the effectiveness of future anti-obesity treatments. Funding: Canadian Institutes of Health Research (PJT-168876).
Marcotte et al. (Thu,) conducted a observational in Obesity (n=540). BMI polygenic scores (PGS) was evaluated on mean-over-time excessive body weight loss (%EBWL) (Explained variance 39.6%). A full-adjusted BMI polygenic score model explained 39.6% of the mean-over-time excessive body weight loss in patients undergoing biliopancreatic diversion with duodenal switch.