We report the synthesis, characterization, and catalytic activity of two new palladium(II) complexes featuring benzodoxazol-2-yl-based pincer ligands, namely, Pd(NNNmor)Cl (C1) Pd(NNNpic)Cl (C2), and (where NNNmor = N-(2-(benzodoxazol-2-yl)phenyl)-2-morpholinoacetamide) NNNpic = N-(2-(benzodoxazol-2-yl)phenyl) picolinamide. Structures of the ligands and the complexes were confirmed by FTIR, NMR and high-resolution mass spectrometry (HRMS). Further, the molecular structure of C2 in the solid state was confirmed by single-crystal X-ray diffraction. The complex showed pincer coordination mode with a distorted square planar geometry. The catalytic activity of these Pd(II) complexes in the direct arylation of indazoles and other heteroarenes with aryl bromides has been explored, with complex C2 exhibiting better reactivity compared to complex C1. Mechanistic investigations revealed that the catalytic pathway involves a PdII–PdIV-PdII cycle. The results are supported by DFT calculations.
Swami et al. (Mon,) studied this question.