Caloric restriction attenuates age-related liver and kidney alterations in mice: Histological evidence.

Key Points

• The study aims to investigate the effects of caloric restriction on age-related changes in liver and kidney structures in mice.
• Long-term caloric restriction was implemented in mice throughout aging.
• Hepatic and renal histological assessments were conducted to evaluate tissue architecture and health.
• Metabolic overload, fibrotic remodeling, and cellular senescence were analyzed alongside SIRT1 and p53 profiles.
• Hepatic and renal structures showed preserved histoarchitecture with caloric restriction.
• Caloric restriction reduced signs of fibrotic remodeling in both liver and kidneys.
• SIRT1/acetyl-p53 levels were sustained, indicating lower p53 activation associated with caloric restriction.