Glutathione-responsive conjugates of hyperbranched polyoxidized glutathione and camptothecin for cancer therapy

Key Points

• To explore the use of oxidized glutathione as a carrier for the anticancer drug camptothecin, aiming to reduce systemic toxicity.
• Synthesize conjugates of oxidized glutathione and camptothecin.
• Evaluate the responsiveness of the conjugates to glutathione levels.
• Assess the potential for targeted drug delivery to cancer cells.
• Conjugates demonstrated improved delivery of camptothecin.
• Significant reduction in systemic toxicity compared to standard camptothecin treatment.