What question did this study set out to answer?

This research aims to understand the role of THBS4 in pulmonary hypertension and its signaling pathways.

March 26, 2026Open Access

THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling

JZJie Zeng DLDengyuan LiKunming University of Science and Technology JWJia‐Yi WangZhejiang International Studies University

Key Points

This research aims to understand the role of THBS4 in pulmonary hypertension and its signaling pathways.
Identification of THBS4 as a regulator of pulmonary vascular remodeling
Analysis of THBS4-TGF-β/SMAD2 signaling interactions
Evaluation of THBS4 targeting as a potential therapeutic strategy
THBS4 is implicated in the regulation of TGF-β/SMAD2 signaling in pulmonary hypertension
Blocking THBS4 can reduce vascular remodeling related to pulmonary hypertension
THBS4 presents a novel therapeutic target for managing pulmonary hypertension

Abstract

Our findings identify THBS4 as a central regulator in a self-reinforcing THBS4-TGF-β/SMAD2 signaling axis driving pulmonary vascular remodeling. Targeting THBS4 represents a promising therapeutic strategy to mitigate pathological vascular remodeling in pulmonary hypertension.

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Cite This Study

Zeng et al. (Tue,) studied this question.

synapsesocial.com/papers/69c4ccc9fdc3bde4489185cf https://doi.org/https://doi.org/10.1161/hypertensionaha.125.25968

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