Integrated synthesis, antiproliferative potential, and in silico analysis of novel pyrazole-based hydrazones derived from 3-(2-(4-chlorophenyl)hydrazineylidene)-5-phenylfuran-2(3 H )-one

Key Points

• The aim is to synthesize pyrazole-based hydrazones and evaluate their antiproliferative activity against cancer cell lines.
• Synthesis of pyrazoles from azofuranone
• Evaluation of antiproliferative activity in vitro
• Testing against MCF-7 and HCT-116 cancer cell lines
• Pyrazole-based hydrazones exhibited promising antiproliferative activity
• Significant effects observed against MCF-7 and HCT-116 cell lines