What is the clinical evidence from this study?

Study design: Cohort. Population: In-hospital cardiac arrest in overweight and obese patients (n=679). Intervention: LUCAS assisted CPR vs. Manual CPR. Primary outcome: 24-hour mortality (OR 1.54, 95% CI 0.94-2.53, p=0.09).

What question did this study set out to answer?

The study aims to evaluate the impact of LUCAS-assisted CPR versus manual CPR on survival outcomes in overweight and obese patients after in-hospital cardiac arrest.

March 26, 2026

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1433: Lucas vs Manual CPR in Obese in-Hospital Cardiac Arrest: Survival Outcome

Q: What does this research mean for the field?

LUCAS-assisted mechanical CPR does not significantly improve 24-hour or 60-day mortality compared to manual CPR in overweight and obese patients experiencing in-hospital cardiac arrest. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

APAryan PathakD.Y. Patil University IHIván HuespeHeart Failure & Transplant APAayushi PareekHeart Failure & Transplant

Key Result

LUCAS-assisted mechanical CPR did not significantly improve 24-hour mortality (OR 1.54; 95% CI 0.94-2.53; p=0.09) or 60-day mortality versus manual CPR in overweight and obese IHCA patients.

Key Points

The study aims to evaluate the impact of LUCAS-assisted CPR versus manual CPR on survival outcomes in overweight and obese patients after in-hospital cardiac arrest.
Multicenter retrospective cohort study involving adult patients from seven hospitals.
Excluded cases with less than 4 minutes of arrest or no BMI record.
Used Inverse-probability-of-treatment weighting (IPTW) to adjust for demographics and comorbidities.
Compared 24-hour and 60-day mortality using IPTW-weighted logistic regression.
Fitted restricted cubic spline models to explore effect modification by BMI.
679 patients analyzed with 595 receiving manual CPR and 84 receiving LUCAS-assisted CPR.
No significant difference in 24-hour mortality (OR 1.54) or 60-day mortality (OR 1.83) between groups.
Mortality rates increased moderately from BMI 25-28 kg/m2, plateauing above 28 kg/m2 in both CPR groups.
No significant interaction between LUCAS use and BMI affecting outcomes.

Study Design

Type

Cohort (n=679)

Multicenter

Yes

Structured PICO

Does LUCAS-assisted mechanical CPR improve 24-hour or 60-day mortality compared to manual CPR in overweight and obese patients with in-hospital cardiac arrest?

Population

679 adult patients with in-hospital cardiac arrest (IHCA) who are overweight (BMI ≥ 25 kg/m2) or obese (BMI ≥ 30 kg/m2) across seven Mayo Clinic hospitals. Excluded: cardiac arrests lasting < 4 minutes or patients without a BMI record.

Intervention

LUCAS-assisted mechanical CPR (n=84)

Comparator

High quality manual CPR (n=595)

Outcome

24-hour mortality and 60-day mortalityhard clinical

In overweight and obese patients experiencing in-hospital cardiac arrest, the use of LUCAS-assisted mechanical CPR does not significantly improve 24-hour or 60-day mortality compared to high-quality manual compressions.

Main Result

Effect estimate: OR 1.54 (95% CI 0.94-2.53)

p-value: p=0.09

Abstract

Introduction: Obesity is a growing global health concern that not only increases the risk of mortality but also complicates the clinical management of critically ill patients, particularly during cardiopulmonary resuscitation (CPR). This study aims to compare 24-hour and 60-day survival after in-hospital cardiac arrest (IHCA) in overweight (BMI ≥ 25 kg/m2) and obese patients (BMI ≥ 30 kg/m2) resuscitated with LUCAS assisted versus manual CPR, and to determine whether BMI (body mass index) modifies this association. Methods: Multicenter retrospective cohort of adult IHCA events at seven Mayo Clinic hospitals from January 2019 to January 2025. Cardiac arrests 0.14), indicating consistent effects across the BMI spectrum. Conclusions: In overweight and obese IHCA patients, LUCAS-assisted mechanical CPR did not improve 24-hour or 60-day mortality versus high quality manual compressions, and effectiveness was independent of BMI.

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Cite This Study

Pathak et al. (Sun,) conducted a cohort in In-hospital cardiac arrest in overweight and obese patients (n=679). LUCAS assisted CPR vs. Manual CPR was evaluated on 24-hour mortality (OR 1.54, 95% CI 0.94-2.53, p=0.09). LUCAS-assisted mechanical CPR did not significantly improve 24-hour mortality (OR 1.54; 95% CI 0.94-2.53; p=0.09) or 60-day mortality versus manual CPR in overweight and obese IHCA patients.

synapsesocial.com/papers/69c4ccf7fdc3bde448918b83 https://doi.org/https://doi.org/10.1097/01.ccm.0001187728.98742.75

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