Real-world clinical outcomes of doxycycline post-exposure prophylaxis for bacterial STI prevention

Key Points

• The aim is to evaluate the effectiveness of doxycycline as a post-exposure prophylaxis for preventing bacterial STIs in a real-world context.
• Assessment of DoxyPEP awareness and uptake among different demographics.
• Analysis of STI diagnoses, particularly chlamydia, gonorrhea, and syphilis, in relation to DoxyPEP use.
• Comparison of STI rates between users and non-users of DoxyPEP.
• DoxyPEP awareness and usage were notably high, especially among cisgender men and people living with HIV (PLWH).
• DoxyPEP use correlated with a lower number of chlamydia diagnoses.
• Higher rates of gonorrhea were observed, with no significant benefit seen for syphilis prevention.