What question did this study set out to answer?

The research aims to explore how adiponectin influences inflammation and keratinocyte behavior in the context of psoriasis.

March 26, 2026Open Access

Adiponectin Inhibits AURKA to Suppress Inflammation in TNF‐α‐induced Keratinocytes and Attenuates Psoriatic Dermatitis in Mice

Key Points

The research aims to explore how adiponectin influences inflammation and keratinocyte behavior in the context of psoriasis.
Investigated the effects of adiponectin on TNF-α-induced keratinocytes
Assessed keratinocyte hyperproliferation and inflammatory markers
Evaluated the impact of adiponectin on IMQ-induced psoriatic dermatitis in a mouse model
Adiponectin significantly inhibited keratinocyte hyperproliferation
Reduced inflammation markers in TNF-α-treated keratinocytes
APN treatment improved severity of psoriatic dermatitis in mice

Abstract

Our findings suggest that APN inhibits keratinocyte hyperproliferation and suppresses inflammation in TNF-α-induced keratinocytes. Moreover, APN treatment attenuates IMQ-induced psoriatic dermatitis in mice, supporting its potential as a therapeutic approach for psoriasis.

Adiponectin Inhibits AURKA to Suppress Inflammation in TNF‐α‐induced Keratinocytes and Attenuates Psoriatic Dermatitis in Mice

Key Points

Abstract

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