Dynamic Fluidization of Hemodynamic Suspensions: High-Frequency Parametric Renormalization of Erythrocyte Aggregation

This work presents a theoretical framework for modifying the rheological behavior of erythrocyte suspensions using high-frequency parametric driving. Modeling whole blood as a shear-thinning colloidal suspension, we analyze the effect of fast, zero-mean oscillatory forcing on intercellular interaction potentials using Floquet averaging techniques. We show that high-frequency driving can renormalize short-range attractive interactions responsible for rouleaux formation, leading to a reduction in effective interaction well depth via a Bessel-function dependence. This mechanism can significantly reduce aggregation tendencies and promote a transition toward a more weakly structured suspension with lower effective viscosity. The model predicts a crossover from a yield-stress, non-Newtonian regime to a more fluid-like state under sufficiently strong driving. This work provides a physically motivated perspective on the dynamic control of aggregation phenomena in soft matter and complex suspensions.