Evidence from systematic reviews demonstrates that 18FFDG PET/CT is a valuable diagnostic tool in FUO/IUO, bacteremia, sepsis, and related infectious/inflammatory conditions, with clinically significant impact on patient management. Strategic patient selection based on clinical risk factors optimizes cost-effectiveness. Future standardization of imaging protocols and prospective comparative studies are needed to define optimal clinical indications across different populations.
Martinello et al. (Sun,) studied this question.