Green synthesis of a 4-hydroxydithiocoumarin-imidazole bis-heterocycle scaffold, and its antiproliferative study and unusual single-crystal XRD pattern

Key Points

• The research aims to synthesize novel bis-heterocycles and evaluate their antiproliferative properties.
• Catalyst-free synthesis of tetra-substituted imidazole-bound bis-heterocycles.
• Utilization of a pseudo-five-component reaction.
• Inclusion of 4-hydroxydithiocoumarin, isocyanide, ammonium acetate, and aryl aldehydes.
• Multiple C–C and C–N bonds formed in one synthesis step.
• Discovery of unusual single-crystal XRD pattern in the resulting compounds.