Pharmacokinetic variability and complex two‐way interactions with cenobamate in patients with refractory epilepsy

Key Points

• The study aims to explore pharmacokinetic variability and interactions of cenobamate in patients with refractory epilepsy.
• Observational study design
• Patients on polytherapy with cenobamate (CNB)
• Analysis of pharmacokinetic data
• Utilization of therapeutic drug monitoring (TDM)
• Observed complex two-way interactions with cenobamate in polytherapy
• Significant variability in pharmacokinetics among patients
• Implications for the importance of therapeutic drug monitoring in managing treatments