Effect of reticulocalbin 3 on monocyte-to-macrophage differentiation in sepsis through modulating autophagy

Key Points

• This research aims to explore how RCN3 influences the differentiation of monocytes into macrophages during sepsis.
• Analyzed the expression of RCN3 in monocytes from septic conditions.
• Investigated the role of RCN3 in modulating autophagy.
• Examined the effects on differentiation pathways leading to macrophage formation.
• Increased levels of RCN3 were found in septic monocytes.
• RCN3 upregulation positively influenced the differentiation process into macrophages.
• Modulation of autophagy was identified as a mechanism through which RCN3 exerts its effects.