Synthesis of the conjugation-ready β-D-rhamnose and β-D-mannose containing trisaccharide O-antigen from Serratia spp. Strains 10.1WK and 1XS

Key Points

• The aim is to synthesize a conjugation-ready trisaccharide O-antigen containing β-D-rhamnose and β-D-mannose.
• Developed a linear synthesis strategy for the trisaccharide O-antigen.
• Prepared a 1,2-cis mannoside from a protected glucoside derivative.
• Isolated intermediate compounds during synthesis.
• Successfully synthesized the target trisaccharide O-antigen.
• Demonstrated feasibility of the linear synthesis approach.