D-Galactose-conjugated pyrimidine thioureas as potent antimicrobial agents: rapid green synthesis, structure-activity relationships and molecular modelling

Key Points

• The aim is to explore the antimicrobial potential of D-galactose-conjugated pyrimidine thioureas and their structure-activity relationships.
• Synthesis of D-galactose-conjugated pyrimidine thioureas using ionic liquid-microwave protocol.
• Utilization of [BMIM][BF4] to enhance reaction efficiency.
• Evaluation of antimicrobial activity against various pathogens.
• Synthesis yielded compounds with excellent yields under optimized conditions.
• Several thioureas showed significant antimicrobial activity.
• Structural features correlated with increased efficacy, aiding in understanding their mechanism.