10 3, TIMP-2*IGFBP7 achieved an AUROC = 0. 904 (95 % CI 0. 845-0. 963), sensitivity 88. 4 %, specificity 88. 7 %, PPV 67. 9 %, NPV 96. 6 %. Biomarker elevation preceded serum creatinine rise by 24-48 h. Three patients required renal replacement therapy; one death occurred due to multiorgan failure. Conclusion: Urinary TIMP-2 and IGFBP7 provide sensitive and specific early detection of AKI in preeclamptic pregnancies. The TIMP-2*IGFBP7 product 0. 938 ng/mL 2 /10 3 identifies women at high risk for PRAKI well before conventional markers rise, supporting early nephroprotective intervention. I have no potential conflict of interest to disclose. I did not use generative AI and AI-assisted technologies in the writing process.
Mizaki et al. (Wed,) studied this question.