Severe α1-Antitrypsin Deficiency and Increased Risk of Gastrointestinal Diseases

Key Points

• This research aims to evaluate the risk of gastrointestinal diseases associated with severe α1-antitrypsin deficiency in individuals with PiZZ.
• Comparative analysis of individuals with PiZZ and the general population
• Assessment of gastrointestinal disease prevalence
• Examination of specific conditions such as Crohn disease and ulcerative colitis.
• Individuals with PiZZ have a higher incidence of gastrointestinal diseases compared to the general population.
• Specific diseases include Crohn disease, ulcerative colitis, and diverticular disease.