Wcn26-5001 Acylcarnitines in Plasma and Urine Associated With Remission of Proteinuria in FSGS/McD: Untargeted Metabolomic Analyses From the Neptune Cohort

Key Points

• This research aims to explore the relationship between acylcarnitines and the remission of proteinuria in patients with FSGS/MCD.
• Performed untargeted metabolomic analyses on plasma and urine samples
• Analyzed the NEPTUNE cohort data
• Investigated pathways related to histidine and carnitine
• Certain acylcarnitines were found to be enriched in patients achieving remission of proteinuria
• Histidine and carnitine pathways showed significant associations with eGFR variability
• Findings suggest microbial metabolism might influence renal function outcomes