renal prognosis.Notably, cast formation retained statistical significance even after additional adjusting for IFTA (HR 1.64;.Furthermore, the inclusion of cast formation into a model containing established prognostic indicators improved the predictive accuracy for renal outcomes (Harrell's C-index: from 0.638 to 0.655; +0.017), suggesting its independent prognostic value, supporting its independent prognostic value.Ordinal logistic regression analysis showed that cast formation was negatively correlated with eGFR and positively associated with the IFTA score, but not with urinary protein excretion or pathologic urinary casts, suggesting that medullary cast formation may reflect localized tubular stress or intratubular obstruction, rather than glomerular impairment.Conclusion: Incorporating medullary findings, particularly fibrosis and cast formation, into renal biopsy assessment may enhance the prediction of renal outcomes beyond conventional cortical parameters.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.
Zhu et al. (Wed,) studied this question.