WCN26-7108 The autophagy enhancer MSL-7 prevents renal fibrosis by activating the autophagy-lysosomal pathway and improving lysosomal stress in a mouse model of CKD | Synapse
March 28, 2026Kidney International Reports0 citationsOpen Access
WCN26-7108 The autophagy enhancer MSL-7 prevents renal fibrosis by activating the autophagy-lysosomal pathway and improving lysosomal stress in a mouse model of CKD
The aim is to evaluate the potential of MSL-7 in preventing renal fibrosis through the autophagy-lysosomal pathway in a mouse model.
Utilized a mouse model of chronic kidney disease (CKD).
Administered MSL-7 to evaluate its effects on autophagy and lysosomal function.
Measured indicators of renal fibrosis and lysosomal stress.
MSL-7 significantly activated the autophagy-lysosomal pathway.
Improved lysosomal function was observed, reducing renal fibrosis.
Treatment led to notable protective effects against CKD progression.
Abstract
in disease pathogenesis and provide potential future therapeutic targets.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.