creatinine was 0.87 mg/dL (0.76-0.97).Sixteen patients (84.2%) met the KDIGO or dCCR4 criteria for AKI; two required temporary in-hospital dialysis, and one of them died during hospitalization.The median duration of CPB was 3.0 (2.6-3.5)hours.The median time to peak levels of uNGAL and uPTM-FetA was both 5.5 hours, with IQR of 4.5-6.3 and 3.7-33.0hours, respectively.The trajectories of uNGAL and uPTM-FetA were highly correlated, showing consistent temporal patterns with similar peak and plateau dynamics from baseline to the first 48 hours of bypass (Figure 1).For dCCR4 and S-Cre-based KDIGO criteria, the median time to AKI were 7 (0-7) and 11 (11-11) hours, respectively (p<0.001).dCCR4 demonstrated a continuous, earlier, and steeper decline until reaching its trough, in contrast to eGFR, which showed a transient hyperfiltration pattern that may delay AKI detection (Figure 2).Conclusion: uPTM-FetA exhibited a dynamic trajectory comparable to that of uNGAL following CPB, and dCCR4 remained a useful marker for earlier AKI detection.Further studies are warranted to validate the prognostic value of both novel injury biomarkers and dCCR4 approaches, either individually or in combination.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.
Subrahmanyam et al. (Wed,) studied this question.