This case demonstrates TFLX-induced transient NDI characterized by: temporal association with TFLX administration, hypotonic urine despite elevated vasopressin, suppressed urinary AQP2, presence of TFLX crystals, and rapid resolution after discontinuation.The underlying pathophysiology is thought to involve the deposition of TFLX crystal in the collecting ducts, which causes mechanical obstruction and disrupts vasopressin-mediated AQP2 trafficking.TFLX-induced crystalluria occurs eight times more frequently in infants than in adults, suggesting age-related vulnerability. Conclusion:We report a case of TFLX-induced crystalline nephropathy that resulted in transient NDI in an infant.This highlights the vulnerability of infants to fluoroquinolone-induced renal complications.When fluoroquinolones are deemed necessary for young children, careful monitoring of parameters such as urine output, specific gravity, and urinary sediment may facilitate the early detection of drug-induced NDI.I have no potential conflict of interest to disclose.I used generative AI and AI-assisted technologies in the writing process.During the preparation of this work, the authors used Claude (Large Language Model by Anthropic) to improve English grammar, phrasing, and clarity.After using this tool/service, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication.
Zaidi et al. (Wed,) studied this question.