In vitro study of spatially-fractionated radiotherapy (SFRT) with gold nanoparticles in cancerous and healthy skin cells

Key Points

• This research aims to explore how gold nanoparticles (AuNPs) enhance DNA damage in different skin cell types during radiotherapy.
• Conducted in vitro experiments using monoculture and co-culture setups
• Administered spatially-fractionated radiotherapy alongside gold nanoparticles
• Measured DNA damage levels following combined therapy
• Monocultures showed up to 1.6-fold increase in DNA damage with combined therapy versus radiation alone
• In co-culture conditions, melanoma cells experienced relatively greater DNA damage from combined treatment
• Findings highlight the potential for selective enhancement of DNA damage in melanoma