Astragalus Polysaccharide Promotes NLRP3 + Macrophages Polarization via Suppression of OGT in Hepatocellular Carcinoma

Key Points

• The aim is to explore how astragalus polysaccharide (APS) influences macrophage polarization and tumor suppression in hepatocellular carcinoma (HCC).
• Examined the effects of APS on hepatocellular carcinoma cells in vitro.
• Analyzed the role of OGT in O-GlcNAcylation processes.
• Assessed polarization of NLRP3+ macrophages in the tumor microenvironment.
• APS inhibits OGT-mediated O-GlcNAcylation, leading to decreased levels of M2 macrophages.
• Promotion of NLRP3+ M1-like tumor-associated macrophages (TAMs) occurs post-APS treatment.
• Enhanced anti-tumor immunity observed, indicating potential therapeutic benefits for HCC.