Salivary insulin-like growth factor-1 (IGF-1) and bone alkaline phosphatase (BALP) levels during mandibular advancement with Twin Block appliance: A longitudinal study

Key Points

• The research aims to explore changes in salivary IGF-1 and BALP levels during treatment with a Twin Block appliance.
• Conducted a longitudinal study measuring salivary IGF-1 and BALP levels.
• Monitored changes over a period of 10 weeks during Twin Block appliance therapy.
• Salivary IGF-1 levels increased significantly within 7-10 days.
• BALP levels peaked between 6-10 weeks of treatment.
• Findings suggest that IGF-1 and BALP may play a key role in the body's response to the appliance.