Seven pairs of new enantiomers, Paecilomyces A-G (1-7), were isolated from the deep-sea-derived fungus Paecilomyces sp. YD-8. Their unprecedented structures, featuring symmetric or single C8-aliphatic chain substitutions on the 1,4-epoxynaphthalene-2,3-dicarboxylic acid core, were elucidated via spectroscopic analysis, X-ray diffraction, and ECD calculations. Several enantiomers (1b, 3a, 4a/4b, and 5b) showed better antithrombotic activity at 6.25 μM than aspirin at 124.9 μM in a zebrafish model, highlighting their therapeutic potential. Moreover, plausible biosynthetic pathways of 1-7 were proposed.
Weng et al. (Wed,) studied this question.