Association between pharmacological tenofovir adherence measures and subsequent 24-week viral load outcomes for people with HIV in South Africa

Key Points

• The aim is to examine the relationship between tenofovir adherence measures and 24-week viral load outcomes in people living with HIV.
• Assessed DBS TFV-DP levels to evaluate adherence.
• Analyzed POC urine TFV to determine recent ART initiation and viraemia.
• Measured viral load and CD4 count after 24 weeks.
• Higher DBS TFV-DP levels correlated with undetectable viraemia at 24 weeks.
• Undetectable POC urine TFV linked to recent ART initiation and current viraemia.
• Lower CD4 counts observed in those with detectable viraemia.