What question did this study set out to answer?

This research aims to develop a new fluorescent probe for the specific detection of endogenous peroxynitrite.

March 28, 2026

Novel Turn-on Fluorescent Probe for Endogenous Peroxynitrite Detection Based on Selective Oxidation of Nitrobenzoyl Formate Ester

Key Points

This research aims to develop a new fluorescent probe for the specific detection of endogenous peroxynitrite.
Designed a turn-on fluorescent probe (EASHC-NO2) for detection.
Utilized intramolecular charge transfer (ICT) mechanism.
Focused on selective oxidation of nitrobenzoyl formate ester for sensing.
Successfully demonstrated fluorescence activation upon peroxynitrite presence.
Proved effective detection of peroxynitrite in biological samples.
Showed high selectivity and sensitivity towards peroxynitrite.

Abstract

A turn-on fluorescent probe (EASHC-NO2) is designed for endogenous peroxynitrite (ONOO⁻) detection. The probe contains a fluorophore with intramolecular charge transfer (ICT) effect and a selective sensing site containing nitro...

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