Silver catalysed asymmetric 3+2 cycloaddition for the construction of 5−5-membered 1,3'-indolyl pyrrole atropisomers

Key Points

• The aim is to develop a silver-catalyzed cycloaddition method to create chiral indolyl pyrroles.
• Used Ag-catalyzed [3+2] cycloaddition reaction
• Combined N-alkynyl ketones with isocyanides
• Focused on synthesizing 5−5-membered indolyl pyrroles
• Evaluated yields and enantioselectivities
• Achieved high yields of product synthesis
• Demonstrated excellent enantioselectivity in reactions
• Successfully produced C-N axial chiral atropisomers