Objectives: The objective of this study is to evaluate the effect of 635 nm photobiomodulation on the rate and magnitude of maxillary canine distalization following extraction of the maxillary first premolars in adult patients. Materials and Methods: This randomized, controlled, split-mouth clinical trial included 18 adult patients undergoing extraction-based orthodontic treatment for Class II malocclusion. Maxillary first premolars were extracted, and canine distalization was performed using nickel–titanium closed-coil springs delivering a constant force of 150 g, supported by orthodontic mini-implants providing absolute anchorage. Photobiomodulation was applied on one randomized side using a 635 nm diode laser operating at 100 mW in continuous-wave mode, with an 8 mm handpiece diameter. Laser irradiation was delivered in contact mode to two application sites per session corresponding to the buccal and palatal aspects of the maxillary canine root, with an exposure time of 60 s per site. Irradiation was performed according to a predefined schedule over a 45-day observation period, while the contralateral side served as a sham-treated control. Tooth movement was assessed by repeated measurements of inter-bracket distance. A linear mixed-effects model was used to analyze the effects of treatment, time, and their interaction on tooth movement dynamics. Results: The linear mixed-effects model revealed a significant interaction between treatment and time (p < 0.001), indicating a greater rate of canine distalization on the photobiomodulation-treated side compared with the control side. Treatment and time also demonstrated significant main effects. After 45 days, the mean cumulative canine displacement was approximately 1.6 mm greater on the photobiomodulation side than on the control side. Age and sex did not significantly influence tooth movement. Conclusions: Photobiomodulation at a wavelength of 635 nm significantly increased the rate of maxillary canine distalization in adult extraction cases over a 45-day observation period.
Matys et al. (Thu,) studied this question.