BRI demonstrates a significant linear association with mortality in the US MASLD population. In the Chinese elderly MASLD population, statistical power was insufficient to draw definitive conclusions about BRI-mortality associations. The observed between-cohort heterogeneity likely reflects multiple factors, including differences in age structure, obesity phenotype, mortality ascertainment methods, and potentially genuine population-specific characteristics. These findings underscore the importance of population-specific validation before extrapolating Western-derived BRI thresholds to Asian populations.
Li et al. (Thu,) studied this question.