Analysis of the Mediating Effect of Vitamin D via the TGF‐β1/Treg Pathway in the Pathogenesis of Childhood Primary Immune Thrombocytopenia

Key Points

• The study investigates how vitamin D affects immune thrombocytopenia in children via the TGF-β1/Treg pathway.
• Analyzed the levels of vitamin D, TGF-β1, and Treg cells in children with newly diagnosed immune thrombocytopenia.
• Evaluated the correlation between these elements to assess their mediating effects.
• Dysregulation of vitamin D, TGF-β1, and Treg cells is observed in affected children.
• TGF-β1 is identified as a key mediator in the regulation of immune thrombocytopenia by vitamin D.