Herbal formulations have gained significant importance due to their safety, cost-effectiveness, and minimal side effects when compared to synthetic products. The present study was aimed at the formulation and evaluation of a polyherbal cream with antiseptic activity using natural plant extracts of Azadirachta indica (Neem), Plectranthus amboinicus (Mexican mint), and Aloe barbadensis (Aloe vera). These plants are well known for their antimicrobial, anti-inflammatory, and wound-healing properties. The polyherbal cream was prepared using suitable excipients by incorporating hydroalcoholic extracts of the selected plants. The formulated cream was evaluated for physicochemical parameters such as appearance, pH, viscosity, spread-ability, homogeneity, wash-ability, and stability. The antiseptic activity of the formulation was assessed using the agar well diffusion method against selected pathogenic microorganisms, including Escherichia coli and Staphylococcus aureus, by measuring the zone of inhibition. The results demonstrated that the polyherbal cream showed satisfactory physicochemical properties and good stability. The formulation exhibited significant antimicrobial activity, indicating a synergistic effect of the combined herbal extracts. The study concludes that the developed polyherbal cream possesses effective antiseptic activity and can serve as a safe and natural alternative to conventional antiseptic creams.
B. et al. (Thu,) studied this question.