What question did this study set out to answer?

The aim is to develop a new organophotocatalytic method for synthesizing polycyclic sultones and sultams.

March 28, 2026

Organophotocatalytic Synthesis of Polycyclic Sultones and Sultams with FSO 2 Cl through Fluorosulfonyl Radical Cation Synthon Strategy

Key Points

The aim is to develop a new organophotocatalytic method for synthesizing polycyclic sultones and sultams.
Utilized sulfuryl chloride fluoride (FSO2Cl) as a radical cation synthon.
Employed readily available propargyl alcohols and amines as starting materials.
Implemented a cascade transformation involving radical fluorosulfonylation and ortho-cyclization.
Successfully constructed a wide range of sultones and sultams.
The transformation occurred under mild conditions.
Demonstrated efficiency in creating complex polycyclic structures.

Abstract

An organophotocatalytic strategy for constructing polycyclic sultones and sultams has been developed. Utilizing sulfuryl chloride fluoride (FSO2Cl) as a SO2 radical cation synthon, a wide range of sultones and sultams were efficiently constructed from readily available propargyl alcohols and amines under mild conditions. This cascade transformation proceeds via radical fluorosulfonylation of alkynes, followed by radical ortho-cyclization and an intramolecular sulfur(VI) fluoride exchange (SuFEx) process.

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Cite This Study

Liu et al. (Thu,) studied this question.

synapsesocial.com/papers/69c772d98bbfbc51511e34e8 https://doi.org/https://doi.org/10.1021/acs.orglett.6c00689

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