What question did this study set out to answer?

This study aims to compare immune features in EBV-positive and negative Burkitt lymphoma, focusing on reactive oxygen species and platelet activation.

March 29, 2026Open Access

Immune disparities in the TME of EBV+ and EBV- BL: role of ROS generation pathways and platelet activation

MSMaria Chiara SicilianoUniversity of Siena GBGiorgio BertolazziUniversità degli Studi di Enna Kore SGSelina GlaserUniversität Ulm

Key Points

This study aims to compare immune features in EBV-positive and negative Burkitt lymphoma, focusing on reactive oxygen species and platelet activation.
Analyzed immune profiles of EBV+ and EBV- Burkitt lymphoma cases
Examined macrophage polarization and CD8+ T cell infiltration
Evaluated interferon-gamma signalling pathways
EBV+ Burkitt lymphoma showed M1 macrophages and up-regulated interferon-gamma signalling
Increased CD8+ T cell infiltration in EBV+ cases with granulomatous reaction
3 out of 7 EBV+ cases experienced spontaneous regression

Abstract

Burkitt Lymphoma (BL) cases with typical "starry sky" pattern or rare "granoulomatous reaction" 1 .Notably, the EBV-positive BL (EBV+ BL) cases with granulomatous reactions exhibited a unique immune signature with M1-polarized macrophages, up-regulation of interferon-gamma (IFNG) signalling, increased infiltration of cytotoxic CD8+ T cells and a favourable clinical outcome with spontaneous regression in 3 out of 7 cases.On the other hand,

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