What question did this study set out to answer?

The research aims to explore the effectiveness of anti-PD-L1 antibody-conjugated magnetoliposomes for hyperthermia treatment in bladder cancer.

March 29, 2026International Journal of Hyperthermia0 citationsOpen Access

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Enhanced magnetic hyperthermia using anti-PD-L1 antibody-conjugated magnetoliposomes in a murine subcutaneous bladder cancer model

MGMasakazu Gonda NKNoriyasu Kawai DIDaiki Ishikawa

Key Points

The research aims to explore the effectiveness of anti-PD-L1 antibody-conjugated magnetoliposomes for hyperthermia treatment in bladder cancer.
Utilized magnetoliposomes conjugated with anti-PD-L1 antibodies.
Implemented magnetic hyperthermia in a murine subcutaneous bladder cancer model.
Conducted effectiveness assessments of the treatment strategy.
Demonstrated enhanced hyperthermia effect using the conjugated nanoparticles.
Supported the potential of combined treatments for bladder cancer therapy.

Abstract

Our αPD-L1@MCL enables hyperthermia with magnetic nanoparticles and immunotherapy with an anti-PD-L1 antibody. These findings support further development of hyperthermia mediated by anti-PD-L1 antibody-conjugated magnetic nanoparticles as a promising therapeutic strategy for BC.

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Cite This Study

Gonda et al. (Thu,) studied this question.

synapsesocial.com/papers/69c8c15ade0f0f753b39bc9f https://doi.org/https://doi.org/10.1080/02656736.2026.2645413

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