What question did this study set out to answer?

To explore the impact of immune checkpoint inhibitors followed by surgery on advanced gastric cancer with liver metastases.

March 29, 2026Surgical Case Reports0 citationsOpen Access

Pathological Complete Response after Surgery following Chemotherapy with Immune Checkpoint Inhibitors for Gastric Cancer with Liver Metastases: Two Case Reports

KNKazuki NISHINO MHMichitaka Honda HKHirohito Kakinuma

Key Points

To explore the impact of immune checkpoint inhibitors followed by surgery on advanced gastric cancer with liver metastases.
Reported two case studies involving patients with advanced gastric cancer and liver metastases.
Administered immune checkpoint inhibitors as a part of pharmacotherapy prior to surgical interventions.
Performed gastrectomy and hepatectomy after chemotherapy with immune checkpoint inhibitors.
Both cases achieved a pathological complete response after surgical intervention.
Surgery following immune checkpoint inhibitor therapy showed potential for improving patient prognosis.

Abstract

INTRODUCTION: In recent years, advances in pharmacotherapy, including the introduction of immune checkpoint inhibitors (ICIs), have affected treatment strategies for advanced gastric cancer. Surgical intervention after systemic therapy has the potential to improve the prognosis of patients with advanced gastric cancer and liver metastases. Herein, we report two cases in which gastrectomy and hepatectomy were performed after pharmacotherapy with ICIs, resulting in a pathological complete response.

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