Abstract Epilepsy is a major neurological disorder that affects individuals across all age groups and can significantly impair their quality of life. Although pharmacological treatments are available, there remains a need for complementary non‐pharmacological lifestyle interventions. Music‐based intervention (MBI) is a possible option, as it is non‐invasive, cost‐effective, and easily implemented. This scoping review aims to identify and describe MBIs used in the management of epilepsy. A systematic search was conducted from April 9 to June 10, 2025, using two electronic databases: Ovid Medline and Scopus. The protocol was prospectively registered with the Research Ethics Committee of Universiti Kebangsaan Malaysia (FF‐2025‐173) and PROSPERO (CRD420251119617). Of the 3977 articles identified, 21 studies investigating MBIs for epilepsy met the inclusion criteria. Ten studies were rated as having a high risk of bias based on the Cochrane risk‐of‐bias assessment tool. The remaining studies provided Class II evidence according to both the GRADE and OCEBM frameworks. Most studies used passive listening of pre‐recorded Mozart K.448 for intervention. Overall, MBIs were assigned a Level C recommendation for epilepsy. MBIs for epilepsy require further investigations with robust study designs and a standardized protocol. Heterogeneous study designs and small samples are likely barriers to meaningful clinical translation. Therefore, the rating of recommendations only serves as a point of reference. Future avenues include live performance and reminiscence elements.
Yap et al. (Fri,) studied this question.