A 7-year-old girl with high-risk neuroblastoma was enrolled in a clinical trial. 18F-MFBG PET/CT revealed increased radiotracer accumulation anterior to the left first rib. A metastatic lesion could not be ruled out. Subsequent 68Ga-DOTATATE PET/CT also demonstrated abnormal tracer uptake in the same region. Additional imaging and clinical evaluation confirmed the finding to represent physiological uptake in the stellate ganglion. This case illustrates that false-positive uptake on both 18F-MFBG and 68Ga-DOTATATE PET/CT may occur in the stellate ganglion in pediatric patients and should therefore be considered in the differential diagnosis of focal tracer accumulation in the upper thoracic region.
Li et al. (Tue,) studied this question.