Solvent-controlled stereoselective supramolecular synthesis: a case of diastereomeric dimers of 16- S -dihydrosteviol

Key Points

• This research aims to explore how different solvents affect the stereoselectivity in the synthesis of diastereomeric dimers of a steviol derivative.
• Investigating supramolecular dynamic stereochemistry
• Synthesis of homochiral dimers in various solvents
• Characterization of the dimers and their stereochemical properties
• Two distinct types of homochiral dimers were formed depending on the solvent used
• The study demonstrated significant stereochemical differences between the dimers
• The findings suggest that solvent choice is crucial in directing the stereochemical outcome