Abstract Chronic tinnitus affects 10–33% of adults and significantly impairs their quality of life. Vitamin B12 deficiency may contribute to tinnitus through demyelination and impaired Central auditory inhibition; however, evidence remains limited. This study aimed to evaluate The association between serum vitamin B12 levels and tinnitus severity in adults with chronic Tinnitus. Methods This prospective observational study was conducted over 18 months (January 2022–June 2023) at a tertiary care hospital in India. Fifty adults (≥ 18 years) with chronic subjective Tinnitus (> 3 months duration) were enrolled. The exclusion criteria included objective or Pulsatile tinnitus, vascular causes (e.g. carotid stenosis), non-B12-related anaemia, recent B12 supplementation ( 900 Pg/mL). Mean THI and VAS scores were 47.62 ± 12.47 and 4.32 ± 1.04, respectively; 40% Reported severe tinnitus (THI > 50). No statistically significant correlation was observed Between serum B12 levels and the THI (r = 0.006, p = 0.969) or VAS scores (r = − 0.197, p = 0.169). However, B12-deficient participants exhibited higher mean THI (42.8 vs. 48.1) and VAS (4.6 vs. 4.3) scores, though the difference was not statistically significant. Conclusions This study found no significant association between serum vitamin B12 levels and tinnitus Severity in a predominantly B12-replete cohort. Nevertheless, a consistent trend toward greater symptom burden in deficient individuals supports targeted screening and justifies future interventional trials with B12 supplementation in patients with tinnitus with deficiency.
Tabassum et al. (Sat,) studied this question.
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