Analysis of Indeterminate Results Caused by High Nil Responses in Interferon-Gamma Release Assay

Key Points

• Examine why high nil responses lead to indeterminate results in interferon-gamma release assays for COVID-19 and HIV/AIDS.
• Analyzed data from interferon-gamma release assays
• Evaluated nil responses with respect to disease conditions
• Compared results across different population samples
• Identified significant correlation between high nil responses and indeterminate results
• Observed varied impacts of nil responses on COVID-19 versus HIV/AIDS tests
• Demonstrated need for better diagnostic criteria due to high indeterminate rates